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Comprehensive Prostate Formula - Helps Maintain A Healthy Prostate, 90 tabs, (Doctor's Best)
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Comprehensive Prostate Formula -
Helps Maintain A Healthy Prostate, 90 tabs, (Doctor's Best)
Comprehensive Prostate Formula contains potent levels of synergistic herbs, nutrients and phytochemicals that have been scientifically researched to support the health and wellness of the prostate gland.* This formula incorporates premier herbal extracts of Saw palmetto, African Pygeum bark and Stinging Nettle root, CardioAid plant sterols, and SelenoExcell, a superior form of the mineral selenium, nutrients that have shown documented benefits for prostate health.- Science-based nutrition
- Dietary supplement
- Promotes optimal prostate health and wellness
- Comprehensive support for prostate health
Comprehensive Prostate Formula also contains effective amounts of vitamins D3 and B6, zinc, and lycopene, which research suggests play important roles in supporting optimal prostate function and general health and well-being.*
Saw palmetto extract is one of the world's leading herbal products for prostate support. Widely-cited clinical studies conducted in the past two decades suggest that saw palmetto extract is beneficial for prostate health and urinary function. For example, in a large open trial, 505 men took 320mg of saw palmetto extract daily for three months. Relatively quickly, positive results were recognized using various measurements such as quality of life score, urinary flow rates, and residual urinary volume. The changes in prostate health that accompany middle age are related to the hormone DHT, or dihydrotestosterone, a metabolite of testosterone. DHT levels rise, and DHT binds to prostate cells, accelerating growth of prostate tissue. Saw palmetto extract acts in part through its inhibition of 5-alpha reductase, an enzyme that controls conversion of testosterone to DHT.
Experimental evidence suggests saw palmetto extract blocks the binding of DHT to prostate cells. The fatty acids and sterols in saw palmetto are believed to be responsible for these actions. These include oleic acid, lauric acid, campesterol, stigmasterol, beta-sitosterol and others. The saw palmetto in Comprehensive Prostate Formula is standardized to contain 290mg fatty acids and sterols, matching the amount of extract used in some successful clinical studies.
Like saw palmetto, African pygeum bark extract contains natural sterols and fatty acids, and purified extracts of it have been used in Europe for decades. Although the mechanisms for its effect have not been clearly established, animal experiments suggest pygeum may work by inhibiting growth factors in prostate cells. The pentacyclic triterpenoids and esters of long-chain fatty alcohols in pygeum, and the phytosterols, especially the β-sitosterols, are thought to be the active components. Pygeum extract is believed to promote healthy prostate function by decreasing hypersensitivity of the detrusor muscle, inhibiting cell proliferation, and maintaining prostate architecture.
Nettle, also known as "stinging nettle," grows wild in forests and fields throughout North America and Europe. Traditionally, nettle root has been used as an enhancer of healthy urinary flow and as an astringent. As far back as 1950, German investigators have observed favorable effects on the prostate with the use of nettle root. These initial findings have been confirmed through case studies, as well as double-blind studies, published mainly in German medical journals. In a double blind study of 134 men, a combination of nettle root extract and pygeum extract taken over a period of 56 days proved effective in promoting healthy urine flow. While the specific active ingredients in nettle for prostate support have not been positively identified, nettle's effect on the prostate may stem from its content of polysaccharides and isolectin. Additionally, it contains lignans that prevent testosterone action that is adverse to prostate health.
A long-term clinical study of 257 men used a combination of saw palmetto and stinging nettle together, revealing efficacy, safety, and a high acceptance level among the research subjects. These researchers used this combination because previous researchers had suggested that there is a synergistic interaction when saw palmetto and nettle are used together for maintenance of prostate health and urinary flow. The subjects taking the combination of herbs in this study reported better results (than those taking placebo) on a quality of life index and selfrating questionnaires that assessed the health of the men’s lower urinary tract. A follow-up study on 219 of these men continued to show the same positive trends, including tolerance of the plant extracts, at 96 weeks from baseline.
The selected vitamins and minerals in Comprehensive Prostate Formula are known to be especially important for prostate health.* Both vitamin E and vitamin B-6 intake were associated with maintenance of a healthy prostate in a study of 27,133 male smokers in Finland, aged 50-69. Since vitamin B-6 can inhibit steroid hormone interactions in the body, a deficiency of vitamin B-6 may expose men to levels of hormones that are counterproductive to prostate health. Similarly, prostaglandins are hormonelike substances that may interfere with healthy prostate maintenance; vitamin E can act as an antagonist to prostaglandins.
The relationship between vitamin D and prostate health is complex. Although both diet and sunlight increase men's vitamin D status, low vitamin D levels are nevertheless all too common in North America. Recently, researchers discovered that genetic factors combined with a low vitamin D status might adversely affect prostate health in some men.
The accumulation of zinc in the prostate has numerous beneficial effects and has been widely studied. In an older male population, supplemental zinc can provide for normal blood levels of this crucial mineral. Comprehensive Prostate Formula includes zinc citrate, a form of zinc that researchers suggest will enhance prostate health by blocking extracellular zinc signaling. When supplementing with zinc, copper supplementation is also advised; therefore, a small amount of copper has been added to this formula to balance the zinc.
Comprehensive Prostate Formula now includes more selenium as SelenoExcell®, a form of selenium experimentally proven to reduce prostate epithelial cell DNA damage in an animal model, upon daily supplementation. Selenium is well known for its role in increasing glutathione peroxidase activity, which in turn empowers cellular antioxidant abilities. Men with low blood concentrations of selenium have a harder time maintaining a healthy prostate.
Lycopene was first implicated as a benefactor of prostate health through epidemiologic studies. As a carotenoid, lycopene is known to be effective due to its antioxidant power; however, this free radical scavenging activity is not the only mechanism by which lycopene enacts a protective effect on the prostate. Lycopene also exerts biochemical influence through cell communication channels and the signaling of cytokines, growth factors, and hormones. Lycopene helps maintain tissue homeostasis (the healthy functioning of cell communities) through its ability to enhance communication across cell junctions of adjacent cells. Lycopene has been shown to increase animal levels of detoxifying enzymes, such as the above-mentioned glutathione peroxidase. Additionally, lycopene was shown to downplay androgen production in an animal model by the same mechanism of action as saw palmetto, inhibition of the 5-alpha-reductase enzyme.
Comprehensive Prostate Formula now includes CardioAid beta-sitosterols. These plant sterols are antagonists to prostaglandin metabolism through their inhibition of cyclo-oxygenase and lipoxygenase, thus benefiting the prostate in a manner similar to the vitamin E included in our proprietary blend of ingredients. β-sitosterol has found success in multiple studies examining its effects on prostate health and healthy urine flow. A systemic review of such studies lauded the efficacy, safety, and subject acceptance of β-sitosterol in prostate studies. Additionally, a subsequent follow-up study of 117 men concluded that the prostatic actions of β-sitosterol remained effective during longterm use, without major side effects during the study.
Comprehensive Prostate Formula approaches prostate and urinary health from both a botanical and a nutritive perspective, with sufficient quantities of ingredients that have been extensively studied in research trials around the world. Although the mechanisms of action are not fully discovered, there appears to be synergistic benefits to combining the botanical ingredients included in this formula.
SUGGESTED USAGE
As a dieatery supplement, take 3 tablets daily, with or without food.
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Comprehensive Prostate Formula -
Helps Maintain A Healthy Prostate, 90 tabs, (Doctor's Best)
Serving size: 3 tablets
Vitamin D(as cholecalciferol) 200IU
Viamine E(as d-alpha tocopheryl succinate) 60IU
Vitamin B6(as pyridoxine hydrochlorid) 50mg
Zinc(as zinc citrate) 15mg
Selenium(as L-selenomethionine) 100mcg
Copper(as copper gluconate) 1mg
Saw Palmetto extract 640mg
African Pygeum extract 100mg
Stinging nettle extract (root) 300mg
Lycopene 10mg
Alanine (as L-Alanine) 400mg
Glutamic acid (as L-Glutamic acid) 400mg
Glycine 400mg
Other Ingredients: cellulose, calcium silicate, croscamellose sodium, silicon dioxide, magnesium stearate, vanillin
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Comprehensive Prostate Formula -
Helps Maintain A Healthy Prostate, 90 tabs, (Doctor's Best)
Editor's rating: 8 out of 10
User's rating:  0%  0%
USER'S OPINION
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Comprehensive Prostate Formula -
Helps Maintain A Healthy Prostate, 90 tabs, (Doctor's Best)
FAQ
What do Doctor’s Best products NOT contain?
Milk, egg, wheat, corn, sugar, sweeteners, starch, salt, preservatives, or waxes. Because only natural products are used, taste, color and odor may vary.
If you’re allergic to shellfish, is it safe to take Glucosamine Sulfate?
People who are allergic to shellfish are allergic to the MEAT, not to the shells. The meat is not used to create the glucosamine, it is the ground-up shell.
Why does Doctor’s Best offer Lignisul MSM and not another brand?
Two major reasons for selecting Lignisul were and continue to be: - 1. It is made in the U.S. by using raw materials which are “grown” in the U.S. (pine trees);
- 2. the quality control used in all aspects of Lignisul’s production are the best in the industry.
The facts about Bioperine: Bioperine is a high purity compound extracted from black pepper and practically devoid of other compounds of black pepper which, like safarole, are contributing to the controversy of black pepper being carcinogenic. Piperine is not a carcinogen, and at a purity level of minimum 98% (Bioperine) it should not pose any concerns related to black pepper or black pepper extract.
Doctor’s Best Gelatin capsule information:
The gelatin used to make Doctor’s Best capsules is manufactured in accordance with strict guidelines that ensure it is BSE-free. The FDA developed these guidelines. Our gelatin is made only from cattle living in non-BSE countries. All Doctor’s Best capsules are in full compliance with the FDA’s guidance for our industry.
What about Veggie Caps?
Unlike ordinary animal-derived gelatin capsules, Veggie Caps are made from 100% pesticide-free plant material. If you’re a strict vegetarian or gelatin capsules present a problem for you, Veggie Caps are right for you.
What is HPLC?
HPLC stands for “High Performance Liquid Chromatography.” this is analytical lab testing method that is used to quantify the active ingredients in herbs. It is considered to be a very sensitive and accurate test. HPLC testing is recognized as a quality benchmark for herbal extracts.
How long should it take for a capsule to dissolve?
Approximately 30-45 minutes. For a 2-piece gelatin capsule, the USP standard for maximum dissolution time is 45 minutes.
How does Celadrin compare with Best Glucosamine?
Celadrin is a complex of fatty acids that can affect the expression of certain cytokines that mediate occasional problems in the joints and other tissues. In this way, Celadrin actually complements the actions of glucosamine, which is a necessary building block for joint and cartilage tissue. Together, Celadrin and glucosamine provide an effective means to maintain the health and integrity of joint tissue.
Why is it important to supplement Calcium with Strontium Bone Maker?
Studies in postmenopausal women diagnosed with osteoporosis showed a strong benefit in women taking strontium plus calcium/Vitamin D versus woment taking calcium/Vitamin D plus a placebo. In one such study of 1,442 women, the strontium group had significant increases in bone mineral density and lumbar risk decreased by 41% compared to those given calcium/Vitamin D plus placebo.
NOTE: Should be taken at a different time of day, preferably 2 hours before or after any calcium supplement. It is also extremely important that adequate calcium and Vitamin D is taken, as strontium can compete with calcium uptake into bone.
What is an “ORAC Value”?
Short for “Oxygen Radical Absorbance Capacity,” ORAC is a widely method which measures the ability of foods and other substances to quench oxygen free radicals. Fruits such as cranberry, strawberry, plum, pink grapefruit, and tomato have very high ORAC values.
GUARANTEE/ SHIPPING INFORMATION
Comprehensive Prostate Formula is shipped in a discrete, unmarked package. Orders are processed immediately and usually take about 3 to 5 working days to be received. We do ask that you try it for 2 to 3 weeks to feel the full effects. Any information received is used only for order processing and shipping purposes. Your information, such as e-mail address, will never be disclosed to a third party.
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Comprehensive Prostate Formula -
Helps Maintain A Healthy Prostate, 90 tabs, (Doctor's Best)
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